Calcitriol plays an important role in promoting bone formation, and D-hormone analogs prevent falls to a greater extent than does ordinary vitamin D. In elderly people, diminished renal function due to aging leads to a decrease in renal conversion to 1,25(OH) 2D 3 12. One study indicated that serum 25(OH)D increased with cholecalciferol supplementation and nearly plateaued after 3–4 months of intervention 11. In an expert roundtable discussion, it was agreed that the daily vitamin D intake should be approximately 800 IU for most postmenopausal women 10. Hanley et al 9 have suggested that adults over 50 years old are at a moderate risk for vitamin D deficiency and recommended the use of a supplement with at least 800–1000 IU of vitamin D 3. The National Osteoporosis Foundation (NOF) recommends an intake of 800 to 1000 international units (IU) of vitamin D per day for adults 50 years and older 8. Current guidelines for vitamin D intakes vary around the world. Therefore, most people require supplements such as cholecalciferol (vitamin D 3) to meet the recommended intake 7. Unlike those of other nutrients, dietary sources of vitamin D are limited. The prevalence of atrophic skin changes in older adults is concomitant with an increased probability of lower 25(OH)D levels 6. A level of 25(OH)D of 21–29 ng/mL indicates a vitamin D insufficiency whereas a level of 30 ng/mL or greater indicates vitamin D sufficiency 5. Most specialties define vitamin D deficiency as 25(OH)D levels below 20 ng/mL 4. Vitamin D status is best evaluated by measuring the serum concentration of 25-hydroxyvitamin D 3. Vitamin D is important for maintaining bone health because it stimulates the synthesis of osteopontin and alkaline phosphatase and inhibits osteoblast apoptosis 2. Vitamin D deficiency is a common health problem that increases the risk of many common and serious diseases, including some cancers, type 1 diabetes, cardiovascular disease, and osteoporosis 1. The vitamin D receptor is found in bone, most tissues and cells in the body. In addition, cholecalciferol (800 IU/d) significantly increased the serum 25(OH)D concentration. We concluded that both cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. The levels of serum intact parathyroid hormone in both the groups were significantly decreased (group A: from 48.56☑2.8 to 39.59☑2.6 pg/mL group B: from 53.67☒0.0 to 40.32☑5.4 pg/mL). The serum calcium levels in both the groups were significantly increased (group A: from 2.36☐.1 to 2.45☐.1 mmol/L group B: from 2.36☐.1 to 2.44☐.1 mmol/L). Results:Īfter the 3-month intervention, the serum 25(OH)D concentration in group A was significantly increased from 16.01±5.0 to 20.02±4.5 ng/mL, while that in group B had no significant change. ![]() ![]() The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25(OH)D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), were measured before and after the intervention. In addition, all the subjects received Caltrate D (calcium plus 125 IU cholecalciferol) daily in the form of one pill. The subjects were divided into 2 groups based on the age and serum 25(OH)D concentration: 50 subjects (group A) received cholecalciferol (800 IU/d), and 50 subjects (group B) received calcitriol (0.25 μg/d) for 3 months. ![]() One hundred Chinese postmenopausal women aged 63.8☗.0 years and with serum 25-hydroxyvitamin D concentration <30 ng/mL were recruited. To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency.
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